BRAND NAME: Nitrostat, Tridil
CLASS: vasodilator, organic nitrate, antianginal

Mechanism of Action:

Smooth muscle relaxant acting on vascular, uterine, bronchial, and intestinal smooth muscle Reduces workload on the heart by causing blood pooling (decreased preload) Arteriolar vasodilation (decreased afterload)

Coronary artery vasodilation Increases blood flow to myocardium Decreases myocardial O2 demand

Indications and Field Use:

Angina Myocardial infarction Congestive heart failure with pulmonary edema


Hypovolemia Increased Intra cranial pressure

Adverse Reactions:

CV: Hypotension, reflex tachycardia, bradycardia, decreased coronary perfusion at high doses (secondary to hypotension), headache secondary to dilation of meningeal vessels.


Incompatibilities/Drug Interactions: Other vasodilators Viagra, Levitra, Cialis

Adult Dosage:

SL for Chest pain: 1/150 gr (0.4 mg) tablet or one full spray, may repeat x 3 SL for Pulmonary edema: 1-2 of the 1/150 gr (0.4 mg) tablets may be given SL every 5-10 minutes as long as the systolic BP is greater 90-100 systolic

** IV infusion during interfacility transport must be given via infusion pump: Start at low range of 5 μg/min and increase in increments of 5 μg every 5 – 10 minutes, monitoring pain and blood pressure until desired hemodynamic or clinical response is achieved (fall in SVR, relief of chest pain); most patients respond to 50-200 μg/min

Pediatric Dosage:

Not used

Routes of Administration:

IV or SL ** IV infusion on interfacility transports; special training and infusion pump required

Onset of Action:


Peak Effects:

5-10 minutes

Duration of Action:

1-10 minutes after IV discontinued

Dosage Forms/Packaging:

Bottles of 25 1/150 grain (0.4 mg) tablets Spray Bottle with 200 metered doses, each 0.4 mg IV form not carried on drug

box, must use infusion pump for interfacility transfers

Arizona Drug Box Supply:


Special Notes:

> NTG is heat and light sensitive; stock rotation assures fresh supply.

> SL: Cautiously administer NTG to a patient who has never received it, consider establishing an IV prior to administration.

> Patients with hypotension should be administered this drug with caution.

> Closely monitor vital signs, cardiac rhythm.

> Bradydysrhythmias and hypotension usually respond to Trendelenburg position; atropine and vasopressors may be administered if needed.

> Monitoring IV nitroglycerin on patients during interfacility transport requires an infusion pump and is limited to prehospital providers that have completed a special training curriculum in accordance with their medical control authorities.

> Shelf expiration of glass vials once opened limited to two weeks.

** Indicates special training requirement 

© Matt Dillard 2012